Article
Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve.
Journal of neurology, neurosurgery, and psychiatry - 1 Jan 2005
Mosconi L, Herholz K, Prohovnik I, Nacmias B, De Cristofaro M T R, Fayyaz M, Bracco L, Sorbi S, Pupi A
Abstract excerpt
BACKGROUND: Clinically apparent Alzheimer's disease (AD) is thought to result when brain tissue damage exceeds a critical threshold of "brain reserve", a process possibly accelerated by the apolipoprotein E (ApoE) E4 allele. The interaction between onset age and ApoE genotype was investigated to assess whether early disease onset (<65 years) in patients carrying the E4 allele is associated with greater cerebral...
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