Article
Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study.
Psychiatry research - 15 Feb 2004
Mosconi Lisa, Sorbi Sandro, Nacmias Benedetta, De Cristofaro Maria Teresa R, Fayyaz Mozhgan, Bracco Laura, Herholz Karl, Pupi Alberto
Abstract excerpt
Previous positron emission tomography (PET) studies with fluorodeoxglucose (FDG) as tracer in healthy elders showed that the epsilon4 allele of the apolipoprotein E (ApoE) gene is disruptive to cerebral glucose metabolism (rCMRglu), possibly through the interaction with the aging process. The present study was aimed at assessing whether this interaction occurs in patients with Alzheimer's disease (AD). Eight-six...
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