Article
A common gain of function of p53 cancer mutants in inducing genetic instability.
Oncogene - 18 Feb 2010
Liu D P, Song H, Xu Y
Abstract excerpt
The critical tumor suppressor p53 is mutated in over half of all human cancers. The majority of p53 cancer mutations are missense mutations, which can be classified into contact mutations that directly disrupt the DNA-binding of p53 but have modest impact on p53 conformation and structural mutations that greatly disrupt p53 conformation. Many p53 cancer mutants, including the hot spot mutations (R175H, R248W and...
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