Article

Gain-of-function and dominant-negative effects of distinct p53 mutations in lung tumours

2018-01-01

Abstract excerpt

Lung cancer is the most common cause of cancer-related mortality worldwide with current treatments providing limited therapeutic benefit in most cases. TP53 (Trp53, p53) mutations occur in approximately 50% of lung adenocarcinoma cases and are associated with poor prognosis and so novel therapies that target these p53 mutant lung tumours are urgently needed. Despite the high frequency of p53 mutations in lung tumo...

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Literature Corpus work: 06dabb40-4a8b-5225-9de9-0c53097fa8fe
DOI: 10.17863/cam.18854

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