Article
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.
Cell - 14 Jun 2002
McGill Gaël G, Horstmann Martin, Widlund Hans R, Du Jinyan, Motyckova Gabriela, Nishimura Emi K, Lin Yi-Ling, Ramaswamy Sridhar, Avery William, Ding Han-Fei, Jordan Siobhán A, Jackson Ian J, Korsmeyer Stanley J, Golub Todd R, Fisher David E
Abstract excerpt
Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and which exhibited phenotypic synergy with Mitf in mice. BCL2's regulation by Mitf was verified in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.