Article
The cartilage proteoglycan deficient mutation, nanomelia, contains a DNA polymorphism in the proteoglycan core protein gene that is genetically linked to the nanomelia phenotype.
Matrix (Stuttgart, Germany) - 1 Feb 1992
Velleman S G, Clark S H
Abstract excerpt
The avian mutation, nanomelia (nm), is an autosomal recessive embryonic lethal. Homozygous embryos show hypoplasia of the limbs and a parrot-like beak. Biochemical studies have associated this phenotype with the absence of the major cartilage specific proteoglycan core protein (Argraves et al., 1...
Topics
- Aggrecans
- Animals
- Chick Embryo
- Chickens
- DNA
- Dwarfism
- Extracellular Matrix Proteins
- Genes, Lethal
- Glycoproteins
- Lectins, C-Type
- Phenotype
- Polymorphism, Genetic