Article
The chondrodystrophy, nanomelia: biosynthesis and processing of the defective aggrecan precursor.
The Biochemical journal - 1 Jul 1994
Vertel B M, Grier B L, Li H, Schwartz N B
Abstract excerpt
The lethal chicken mutation nanomelia leads to severe skeletal defects because of a deficiency of aggrecan, which is the largest aggregating chondroitin sulphate proteoglycan of cartilage. In previous work, we have demonstrated that nanomelic chondrocytes produce a truncated aggrecan precursor th...
Topics
- Aggrecans
- Amino Acid Sequence
- Animals
- Cartilage
- Cartilage Diseases
- Cells, Cultured
- Chick Embryo
- Endoplasmic Reticulum
- Extracellular Matrix
- Extracellular Matrix Proteins
- Genes, Lethal
- Lectins, C-Type
- Molecular Sequence Data
- Mutation
- Poultry Diseases
- Protein Biosynthesis
- Protein Precursors
- Protein Processing, Post-Translational