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Article

1H magnetic resonance spectroscopy of nanomelic chicken cartilage: effect of aggrecan depletion on cartilage T2.

Osteoarthritis and cartilage - 1 Oct 2003

Mosher T J, Chen Q, Smith M B

Abstract excerpt

OBJECTIVE: To determine the effect of proteoglycan depletion on cartilage proton magnetic resonance (MR) spectroscopy T2 using nanomelic chicken cartilage, a genetic mutant that completely lacks aggrecan. DESIGN: Proton MR spectroscopic T2 measurements of normal embryonic and nanomelic femoral epiphyseal cartilage were obtained using a 96-echo pulse sequence with inter-echo delay times increased logarithmically...

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Identifiers

PMID: 13129689
DOI: 10.1016/s1063-4584(03)00155-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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1H magnetic resonance spectroscopy of nanomelic chicken cartilage: effect of aggrecan depletion on cartilage T2.PMID 13129689Read ↗

The nanomelic mutation in the aggrecan gene is expressed in chick chondrocytes and neurons.Semantic proximity Read ↗

Nanomelic chondrocytes synthesize, but fail to translocate, a truncated aggrecan precursor.Semantic proximity Read ↗

Molecular basis of nanomelia, a heritable chondrodystrophy of chicken.Semantic proximity Read ↗

Degenerative joint disease in poultry--differences in composition and morphology of articular cartilage are associated with strain susceptibility.Semantic proximity Read ↗

The cartilage proteoglycan deficient mutation, nanomelia, contains a DNA polymorphism in the proteoglycan core protein gene that is genetically linked to the nanomelia phenotype.Semantic proximity Read ↗

The chondrodystrophy, nanomelia: biosynthesis and processing of the defective aggrecan precursor.Semantic proximity Read ↗

The heterozygous disproportionate micromelia (dmm) mouse: morphological changes in fetal cartilage precede postnatal dwarfism and compared with lethal homozygotes can explain the mild phenotype.Semantic proximity Read ↗

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