Article
Aggrecan core protein is expressed in membranous bone of the chick embryo. Molecular and biomechanical studies of normal and nanomelia embryos.
The Journal of biological chemistry - 15 Mar 1992
Wong M, Lawton T, Goetinck P F, Kuhn J L, Goldstein S A, Bonadio J
Abstract excerpt
The recessive mutation nanomelia blocks the synthesis of a large aggregating proteoglycan (aggrecan) by avian embryo chondrocytes. Lack of aggrecan is associated with short stature, multiple morphological defects in cartilage, and embryo lethality. Bony defects have also been described, but were...
Topics
- Aggrecans
- Animals
- Base Sequence
- Blotting, Northern
- Bone and Bones
- Cells, Cultured
- Chick Embryo
- Chickens
- Chondroitin Sulfate Proteoglycans
- Extracellular Matrix Proteins
- Genes, Recessive
- Lectins, C-Type
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Osteoblasts
- Polymerase Chain Reaction
- Proteoglycans