Molecular basis of nanomelia, a heritable chondrodystrophy of chicken.

doi:10.1016/0945-053x(94)90195-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Molecular basis of nanomelia, a heritable chondrodystrophy of chicken.

Matrix biology : journal of the International Society for Matrix Biology - 1 Aug 1994

Primorac D, Stover M L, Clark S H, Rowe D W

Abstract excerpt

Nanomelia is a recessively inherited connective tissue disorder of chicken affecting cartilage development. Other investigators have demonstrated that it involves low aggrecan production and diminished aggrecan mRNA levels. Based on genetic linkage studies showing a high likelihood that the mutation responsible for the nanomelic phenotype lay within the aggrecan gene, a series of experiments was performed to...

Topics

Aggrecans
Amino Acid Sequence
Animals
Base Sequence
Cartilage Diseases
Cell Nucleus
Chickens
Codon
Cytoplasm
DNA
Exons
Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes

Lectins, C-Type

Molecular Sequence Data

Phenotype

Point Mutation

Poultry Diseases

Source

Open in PubMed

Identifiers

PMID: 7827752
DOI: 10.1016/0945-053x(94)90195-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7827752-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis of nanomelia, a heritable chondrodystrophy of chicken.PMID 7827752Read ↗

The cartilage proteoglycan deficient mutation, nanomelia, contains a DNA polymorphism in the proteoglycan core protein gene that is genetically linked to the nanomelia phenotype.Semantic proximity Read ↗

The chondrodystrophy, nanomelia: biosynthesis and processing of the defective aggrecan precursor.Semantic proximity Read ↗

Screening for carriers of the avian cartilage proteoglycan core protein defect, nanomelia, by denaturing gradient gel electrophoresis.Semantic proximity Read ↗

Nanomelic chondrocytes synthesize, but fail to translocate, a truncated aggrecan precursor.Semantic proximity Read ↗

Premature termination codon in the aggrecan gene of nanomelia and its influence on mRNA transport and stability.Semantic proximity Read ↗

Aggrecan core protein is expressed in membranous bone of the chick embryo. Molecular and biomechanical studies of normal and nanomelia embryos.Semantic proximity Read ↗

Molecular cloning of chicken aggrecan. Structural analyses.Semantic proximity Read ↗

The nanomelic mutation in the aggrecan gene is expressed in chick chondrocytes and neurons.Semantic proximity Read ↗

The crest phenotype in domestic chicken is caused by a 197 bp duplication in the intron of HOXC10.Semantic proximity Read ↗

Mutation analysis of the aggrecan gene in chickens with tibial dyschondroplasia.Semantic proximity Read ↗

Cartilage expression of a type II collagen mutation in an inherited form of osteoarthritis associated with a mild chondrodysplasia.Semantic proximity Read ↗

Characterization of a large deletion associated with a polymorphic block of repeated dinucleotides in the type III procollagen gene (COL3A1) of a patient with Ehlers-Danlos syndrome type IV.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.