Article
Screening for carriers of the avian cartilage proteoglycan core protein defect, nanomelia, by denaturing gradient gel electrophoresis.
The Journal of heredity - 1 Jan 2000
Velleman S G, Haines J S, Pierro L J
Abstract excerpt
The avian mutation, nanomelia, is an autosomal recessive embryonic lethal. Homozygous embryos show hypoplasia of the limbs and a parrot-like beak. Biochemical studies have associated this phenotype with the absence of the major cartilage-specific proteoglycan core protein. In a previous study, a...
Topics
- Aggrecans
- Animals
- Birds
- Crosses, Genetic
- Electrophoresis
- Extracellular Matrix Proteins
- Female
- Genes, Lethal
- Genes, Recessive
- Heterozygote
- Lectins, C-Type
- Male
- Mutation
- Polymorphism, Genetic
- Proteoglycans