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Article

Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas.

Brain pathology (Zurich, Switzerland) - 1 Oct 2004

Mizoguchi Masahiro, Nutt Catherine L, Mohapatra Gayatry, Louis David N

Abstract excerpt

Genetic alterations of PI3K (phosphoinositide 3-kinase) subunits have been documented in a number of tumor types, with increased PI3K activity linked to gene amplification and mutation of catalytic subunits, as well as mutations of regulatory subunits. Among high grade gliomas, activation of the PI3K-AKT signaling pathway through loss of PTEN function is common. We therefore investigated whether genetic...

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Identifiers

PMID: 15605984
DOI: 10.1111/j.1750-3639.2004.tb00080.x
PMCID: PMC8095817

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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