Article
PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.
Molecular cancer research : MCR - 1 Oct 2006
Gallia Gary L, Rand Vikki, Siu I-Mei, Eberhart Charles G, James C David, Marie Suely K N, Oba-Shinjo Sueli M, Carlotti Carlos G, Caballero Otavia L, Simpson Andrew J G, Brock Malcolm V, Massion Pierre P, Carson Benjamin S, Riggins Gregory J
Abstract excerpt
The phosphatidylinositol 3-kinases (PI3K) are a family of enzymes that relay important cellular growth control signals. Recently, a large-scale mutational analysis of eight PI3K and eight PI3K-like genes revealed somatic mutations in PIK3CA, which encodes the p110alpha catalytic subunit of class...
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