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Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme

14 Dec 2014

Abstract excerpt

Structural rearrangements of chromosome 10 are frequently observed in glioblastoma multiforme and over 80 % of tumour samples archived in the catalogue of somatic mutations in cancer database had gene copy number loss for PI4K2A which encodes phosphatidylinositol 4-kinase type IIalpha. PI4K2A loss of heterozygosity mirrored that of PTEN, another enzyme that regulates phosphoinositide levels and also PIK3AP1,...

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PMID: 25502460
DOI: 10.1007/s12035-014-9034-9

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