Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.

Brain pathology (Zurich, Switzerland) - 1 Oct 2003

Knobbe Christiane B, Reifenberger Guido

Abstract excerpt

Glioblastomas frequently carry mutations in the PTEN tumor suppressor gene on 10q23.3. The tumor suppressor properties of Pten are closely related to its inhibitory effect on the phosphatidyl-inositol-3'-kinase (Pi3k)-dependent activation of protein kinase B (Akt) signalling. Here, we report on the analysis of 17 genes related to the Pi3k/Akt signalling pathway for genetic alteration and aberrant expression in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Focal Adhesion Kinase 1
Share to Focal Adhesion Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoric Monoester Hydrolases

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Source

Open in PubMed Open full text

Identifiers

PMID: 14655756
DOI: 10.1111/j.1750-3639.2003.tb00481.x
PMCID: PMC8095764

Genes

PTEN
AKT1
AKT2
AKT3
EGFR
INPPL1
IRS1
IRS2
PDGFRA
PTK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.PMID 14655756Read ↗

Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas.Semantic proximity Read ↗

Genetic alteration and expression of the phosphoinositol‐3‐kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomasSemantic proximity Read ↗

PIK3CA alterations in primary (de novo) and secondary glioblastomas.Semantic proximity Read ↗

PIK3CA mutations in glioblastoma multiforme.Semantic proximity Read ↗

Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma MultiformeSemantic proximity Read ↗

Gliosarcoma Is Driven by Alterations in PI3K/Akt, RAS/MAPK Pathways and Characterized by Collagen Gene Expression SignatureSemantic proximity Read ↗

PIK3CA gene aberrancy and role in targeted therapy of solid malignancies.Semantic proximity Read ↗

Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).Semantic proximity Read ↗

Mutational profiling of kinases in glioblastoma.Semantic proximity Read ↗

PAkt, cyclin D1 and p27/Kip.1 in glioblastomas with and without EGFR amplification and PTEN mutation.Semantic proximity Read ↗

Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.Semantic proximity Read ↗

Targeting the AKT Pathway in GlioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.