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Article

Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.

Cancer research - 1 Aug 2004

Broderick Daniel K, Di Chunhui, Parrett Timothy J, Samuels Yardena R, Cummins Jordan M, McLendon Roger E, Fults Daniel W, Velculescu Victor E, Bigner Darell D, Yan Hai

Abstract excerpt

The phosphatidylinositol 3'-kinase pathway is activated in multiple advanced cancers, including glioblastomas, through inactivation of the PTEN tumor suppressor gene. Recently, mutations in PIK3CA, a member of the family of phosphatidylinositol 3'-kinase catalytic subunits, were identified in a significant fraction (25-30%) of colorectal cancers, gastric cancers, and glioblastomas and in a smaller fraction of...

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Source

Identifiers

PMID: 15289301
DOI: 10.1158/0008-5472.CAN-04-1170

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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