Article
Positioning of positively charged residues in the V3 loop correlates with HIV type 1 syncytium-inducing phenotype.
AIDS research and human retroviruses - 20 Jan 1996
Bhattacharyya D, Brooks B R, Callahan L
Abstract excerpt
Although the V3 loop of the envelope glycoprotein (gp120) plays a role in determining the phenotype, pathogenesis, and tropism of human immunodeficiency virus-1 (HIV-1), there has not been any consistent correlation between structure and phenotype. Theoretically determined structures of the V3 loop of gp120, from 20 different viral strains, 10 syncytium-inducing (SI) and 10 non-syncytium-inducing (NSI) phenotype,...
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