Article
Genetic polymorphism of estrogen metabolizing enzymes in Siberian women with breast cancer.
Genetic testing and molecular biomarkers - 1 Mar 2012
Khvostova Ekaterina P, Pustylnyak Vladimir O, Gulyaeva Lyudmila F
Abstract excerpt
Allelic variants of cytochrome P450: CYP1A1, CYP1A2, CYP19 (aromatase), and the II-phase enzyme sulfotransferase 1A1 (SULT1A1) genes are associated with a high risk of hormone-dependent cancers. We estimated the frequency of these allelic variants in the female population of the Novosibirsk district and their association with the elevated risk of breast cancer. A DNA bank of patients with gynecologic oncology,...
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