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Article

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2005

Dunn Sarah L, Björnholm Marie, Bates Sarah H, Chen Zhibin, Seifert Matthew, Myers Martin G

Abstract excerpt

Leptin is an adipocyte-derived hormone that communicates the status of body energy stores to the brain to regulate feeding and energy balance. The inability of elevated leptin levels to adequately suppress feeding in obesity suggests attenuation of leptin action under these conditions; the activation of feedback circuits due to high leptin levels could contribute to this leptin resistance. Using cultured cells...

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Source

Identifiers

PMID: 15604114
DOI: 10.1210/me.2004-0353

Genes

SOCS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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