Article
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.
The Journal of clinical investigation - 1 Oct 2002
Farooqi I Sadaf, Matarese Giuseppe, Lord Graham M, Keogh Julia M, Lawrence Elizabeth, Agwu Chizo, Sanna Veronica, Jebb Susan A, Perna Francesco, Fontana Silvia, Lechler Robert I, DePaoli Alex M, O'Rahilly Stephen
Abstract excerpt
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in rodents. In contrast, information regarding the roles of this hormone in humans is limited. Three morbidly obese children, who were congenitally deficient in leptin, were treated...
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