Article
Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein.
Nature cell biology - 1 Apr 2006
Muraoka Osamu, Shimizu Takashi, Yabe Taijiro, Nojima Hideaki, Bae Young-Ki, Hashimoto Hisashi, Hibi Masahiko
Abstract excerpt
The Bone morphogenetic protein (Bmp) signalling gradient has a major function in the formation of the dorso-ventral axis. The zebrafish ventralized mutant, ogon, encodes Secreted Frizzled (Sizzled). sizzled is ventrally expressed in a Bmp-dependent manner and is required for the suppression of Bmp signalling on the ventral side of zebrafish embryos. However, it remains unclear how Sizzled inhibits Bmp signalling...
Topics
- Animals
- Body Patterning
- Bone Morphogenetic Proteins
- Cell Polarity
- Cysteine
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Glycoproteins
- Intercellular Signaling Peptides and Proteins
- Metalloproteases
- Morphogenesis
- Oligonucleotides
- Phenotype
- Tolloid-Like Metalloproteinases
- Zebrafish
- Zebrafish Proteins