Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein.

Nature cell biology - 1 Apr 2006

Muraoka Osamu, Shimizu Takashi, Yabe Taijiro, Nojima Hideaki, Bae Young-Ki, Hashimoto Hisashi, Hibi Masahiko

Abstract excerpt

The Bone morphogenetic protein (Bmp) signalling gradient has a major function in the formation of the dorso-ventral axis. The zebrafish ventralized mutant, ogon, encodes Secreted Frizzled (Sizzled). sizzled is ventrally expressed in a Bmp-dependent manner and is required for the suppression of Bmp signalling on the ventral side of zebrafish embryos. However, it remains unclear how Sizzled inhibits Bmp signalling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Polarity

Share to Embryo, Nonmammalian

Share to Intercellular Signaling Peptides and Proteins

Share to Metalloproteases

Share to Oligonucleotides

Share to Zebrafish Proteins

Source

Identifiers

PMID: 16518392
DOI: 10.1038/ncb1379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein.PMID 16518392Read ↗

The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein.Semantic proximity Read ↗

Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases.Semantic proximity Read ↗

Bone morphogenetic protein 1 regulates dorsal-ventral patterning in early Xenopus embryos by degrading chordin, a BMP4 antagonist.Semantic proximity Read ↗

Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.Semantic proximity Read ↗

Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning.Semantic proximity Read ↗

The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo.Semantic proximity Read ↗

BMP-binding modules in chordin: a model for signalling regulation in the extracellular spaceSemantic proximity Read ↗

The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate.Semantic proximity Read ↗

Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists.Semantic proximity Read ↗

Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis.Semantic proximity Read ↗

Different activities of the frizzled-related proteins frzb2 and sizzled2 during Xenopus anteroposterior patterning.Semantic proximity Read ↗

Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordiumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.