Article
Carcinogenic effect of N-nitrosodimethylamine on diploid and triploid zebrafish (Danio rerio).
Toxicologic pathology - 1 Jan 2000
Mizgireuv Igor V, Majorova Irina G, Gorodinskaya V M, Khudoley Veniamin V, Revskoy Sergei Y
Abstract excerpt
Viability of polyploid organisms in lower vertebrates including fish provides an additional tool to investigate genetic mechanisms of neoplastic transformation caused by carcinogens. Here we present data on differential sensitivity of diploid and triploid zebrafish (Danio rerio) to N-nitrosodimethylamine (NDMA) induced hepatocarcinogenesis. The effect of the carcinogen was studied in 100 diploid and 120 triploid...
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