Article
MaGIC: a program to generate targeted marker sets for genome-wide association studies.
BioTechniques - 1 Dec 2004
Simpson Claire L, Hansen Valerie K, Sham Pak C, Collins Andrew, Powell John F, Al-Chalabi Ammar
Abstract excerpt
High-throughput genotyping technologies such as DNA pooling and DNA microarrays mean that whole-genome screens are now practical for complex disease gene discovery using association studies. Because it is currently impractical to use all available markers, a subset is typically selected on the basis of required saturation density. Restricting markers to those within annotated genomic features of interest (e.g.,...
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