Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway.

Oncogene - 20 Jan 2005

Jun Joon-Il, Chung Chul-Woong, Lee Ho-June, Pyo Jong-Ok, Lee Kee Nyung, Kim Nam-Soon, Kim Yong Sung, Yoo Hyang-Sook, Lee Tae-Ho, Kim Eunhee, Jung Yong-Keun

Abstract excerpt

Caspase-8 is the most receptor-proximal, upstream caspase in the caspase cascade and plays a key role in cell death triggered by various death receptors. Here, we addressed the role of endogenous caspase-8 in tumor necrosis factor (TNF)-alpha-induced activation of NF-kappaB. Direct targeting of caspase-8 with siRNA and antisense (AS) approaches abolished TNF-alpha-induced activation of NF-kappaB in NIH3T3, HeLa,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Aspartic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Binding Proteins

Share to Caspase 8

Share to Caspase Inhibitors

Share to Caspases

Share to NF-kappa B

Share to TNF Receptor-Associated Factor 2

Source

Identifiers

PMID: 15592525
DOI: 10.1038/sj.onc.1208186

Genes

TNF
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway.PMID 15592525Read ↗

Activation of the NF-kappaB pathway by caspase 8 and its homologs.Semantic proximity Read ↗

Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha.Semantic proximity Read ↗

Functions of caspase 8: The identified and the mysteriousSemantic proximity Read ↗

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.Semantic proximity Read ↗

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.Semantic proximity Read ↗

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling.Semantic proximity Read ↗

Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction.Semantic proximity Read ↗

Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death.Semantic proximity Read ↗

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade.Semantic proximity Read ↗

Constitutive NF-κB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic miceSemantic proximity Read ↗

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis.Semantic proximity Read ↗

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.