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Article

Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death.

Neurobiology of disease - 1 Dec 2003

Chung Chul-Woong, Hong Yeon-Mi, Song Sungmin, Woo Ha-Na, Choi Yun-Hee, Rohn Troy, Jung Yong-Keun

Abstract excerpt

Abnormal Tau protein is known to be closely associated with several neurodegenerative diseases. Previously, we showed that Tau was cleaved by caspase-3 to generate the cleavage product lacking the C-terminus (DeltaTau-1) during neuronal cell death. Here we characterized caspase-8-dependent neurotoxicity of the truncated Tau. Introduction of DeltaTau-1 into primary hippocampal neurons induced loss of neurites in a...

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PMID: 14678771
DOI: 10.1016/j.nbd.2003.08.017

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FADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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