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Article

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade.

Cancer research - 15 Dec 2000

Droin N, Beauchemin M, Solary E, Bertrand R

Abstract excerpt

Procaspase-2 is one of the aspartate-specific cysteine proteases that are activated in response to various apoptotic stimuli. Two isoforms of human procaspase-2 have been described initially. Overexpression of the long isoform (caspase-2L) promotes cell death whereas the short isoform (caspase-2S) antagonizes some apoptotic pathways. In the present study, we identified two additional CASP-2 mRNAs, designated...

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PMID: 11156409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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