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Article

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

Science (New York, N.Y.) - 4 Mar 2005

Su Helen, Bidère Nicolas, Zheng Lixin, Cubre Alan, Sakai Keiko, Dale Janet, Salmena Leonardo, Hakem Razqallah, Straus Stephen, Lenardo Michael

Abstract excerpt

Caspase-8, a proapoptotic protease, has an essential role in lymphocyte activation and protective immunity. We show that caspase-8 deficiency (CED) in humans and mice specifically abolishes activation of the transcription factor nuclear factor kappaB (NF-kappaB) after stimulation through antigen receptors, Fc receptors, or Toll-like receptor 4 in T, B, and natural killer cells. Caspase-8 also causes the alphabeta...

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Share to Amino Acid Chloromethyl Ketones
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15746428
DOI: 10.1126/science.1104765

Genes

MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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