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Article

Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha.

The Journal of biological chemistry - 5 Nov 2004

Imamura Ryu, Konaka Kenji, Matsumoto Norihiko, Hasegawa Mizuho, Fukui Masayuki, Mukaida Naofumi, Kinoshita Takeshi, Suda Takashi

Abstract excerpt

Fas ligand (FasL) has been well characterized as a death factor. However, recent studies revealed that FasL possesses inflammatory activity. Here we found that FasL induces production of the inflammatory chemokine IL-8 without inducing apoptosis in HEK293 cells. Reporter gene assays involving wild-type and mutated IL-8 promoters and NF-kappaB- and AP-1 reporter constructs indicated that an FasL-induced NF-kappaB...

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Source

Identifiers

PMID: 15337758
DOI: 10.1074/jbc.M403226200

Genes

TNF
FADD
TRADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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