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Article

Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction.

Cell death & disease - 6 Aug 2021

Cui Zhibin, Dabas Hadas, Leonard Brandon C, Shiah Jamie V, Grandis Jennifer R, Johnson Daniel E

Abstract excerpt

The cysteine protease, caspase-8, undergoes dimerization, processing, and activation following stimulation of cells with death ligands such as TRAIL, and mediates TRAIL induction of the extrinsic apoptosis pathway. In addition, caspase-8 mediates TRAIL-induced activation of NF-κB and upregulation of immunosuppressive chemokines/cytokines, via a mechanism independent of caspase-8 catalytic activity. The gene...

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Identifiers

PMID: 34362880
DOI: 10.1038/s41419-021-04066-z
PMCID: PMC8346537

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