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Article

Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas.

Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2005

Nakamura Mitsutoshi, Ishida Eiwa, Shimada Keiji, Kishi Munehiro, Nakase Hiroyuki, Sakaki Toshisuke, Konishi Noboru

Abstract excerpt

Frequent allelic losses on the long arm of chromosome 22 (22q) in gliomas indicate the presence of tumor suppressor gene (TSG) at this location. However, the target gene(s) residing in this chromosome are still unknown and their putative roles in the development of astrocytic tumors, especially in secondary glioblastoma, have not yet been defined. To compile a precise physical map for the region of common...

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PMID: 15592495
DOI: 10.1038/labinvest.3700223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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