Article
Loss of heterozygosity of TRIM3 in malignant gliomas.
BMC cancer - 27 Feb 2009
Boulay Jean-Louis, Stiefel Urs, Taylor Elisabeth, Dolder Béatrice, Merlo Adrian, Hirth Frank
Abstract excerpt
BACKGROUND: Malignant gliomas are frequent primary brain tumors associated with poor prognosis and very limited response to conventional chemo- and radio-therapies. Besides sharing common growth features with other types of solid tumors, gliomas are highly invasive into adjacent brain tissue, which renders them particularly aggressive and their surgical resection inefficient. Therefore, insights into glioma...
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