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Article

Fine mapping of chromosome 22q tumor suppressor gene candidate regions in astrocytoma.

International journal of cancer - 1 Mar 2004

Hartmann Christian, Nümann Astrid, Mueller Wolf, Holtkamp Nikola, Simon Matthias, von Deimling Andreas

Abstract excerpt

Astrocytomas and glioblastomas are the most frequent primary brain tumors in adults. Mutations and altered expression of multiple genes have been found to contribute to the genesis of these tumors. However, many factors in the genesis of astrocytic gliomas are not resolved yet. The frequent losses on several chromosomes indicate the role of still unidentified tumor suppressor genes. Loss of heterozygosity (LOH)...

Topics

Astrocytoma
Biomarkers, Tumor
Brain Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 22
DNA
DNA Mutational Analysis
Gene Deletion
Genetic Markers
Humans
Loss of Heterozygosity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Repeats

Models, Genetic

Mutation

Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 14712485
DOI: 10.1002/ijc.11638

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