Article
Identification of a consistent region of allelic loss on 1p32 in meningiomas: correlation with increased morbidity.
Cancer research - 1 Aug 1998
Sulman E P, Dumanski J P, White P S, Zhao H, Maris J M, Mathiesen T, Bruder C, Cnaan A, Brodeur G M
Abstract excerpt
Meningioma is a common tumor of the central nervous system. Deletions of the short arm of chromosome 1 (1p) are the second most commonly observed chromosomal abnormality in these tumors. Here, we analyzed tumor and normal DNAs from 157 meningioma patients using PCR-based polymorphic loci. Loss of heterozygosity (LOH) for at least one informative marker on 1p was observed in 54 cases (34%), whereas LOH on 1q...
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