Article
UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 1998
Ando Y, Saka H, Asai G, Sugiura S, Shimokata K, Kamataki T
Abstract excerpt
BACKGROUND: Irinotecan (CPT-11) is metabolized by esterase to form a SN-38, which is further conjugated by UGT1A1. Genetic polymorphism has been shown in a promoter region of UGT1A1 and is related to its activity. We investigated whether there might be an inter-individual difference in pharmacoki...
Topics
- Aged
- Antineoplastic Agents, Phytogenic
- Camptothecin
- Genotype
- Glucuronosyltransferase
- Humans
- Irinotecan
- Lung Neoplasms
- Male
- Middle Aged
- Polymorphism, Genetic
- Promoter Regions, Genetic
- TATA Box