Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families.

doi:10.1093/hmg/ddg270

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Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families.

Human molecular genetics - 15 Oct 2003

Pankratz Nathan, Nichols William C, Uniacke Sean K, Halter Cheryl, Murrell Jill, Rudolph Alice, Shults Clifford W, Conneally P Michael, Foroud Tatiana

Abstract excerpt

Parkinson disease (PD) is the second most common neurodegenerative disorder. We studied 754 affected individuals, comprising 425 sibling pairs, to identify PD susceptibility genes. Screening of the parkin gene was performed in a subset of the sample having earlier age of PD onset or a positive LOD score with a marker in the parkin gene. All subjects were evaluated using a rigorous neurological assessment. Two...

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Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families.

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