Article
Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis but mildly increases its severity after immunization.
Endocrinology - 1 Mar 2005
Kimura Hiroaki, Kimura Miho, Tzou Shey-Cherng, Chen Yen-Chun, Suzuki Koichi, Rose Noel R, Caturegli Patrizio
Abstract excerpt
Class II major histocompatibility complex (MHC) molecules are classically expressed on antigen-presenting cells of the hematopoietic lineage but have also been described on epithelial cells in association with autoimmunity. In this context, however, it remains debatable whether class II MHC molecules are the initiating event or rather the consequence of the autoimmune attack. In addition, the role of epithelial...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Autoimmune Diseases
- Cohort Studies
- DNA, Complementary
- Epithelial Cells
- Flow Cytometry
- Genes, MHC Class II
- Histocompatibility Antigens Class II