The interaction of basic science and population-based research: autoimmune thyroiditis as a case history.

Abstract excerpt

This brief commentary illustrates how laboratory research compliments populational research. The finding that susceptibility to autoimmune thyroid disease in animals is due to the additive effects of a number of unrelated genes led to a field study of a genetically predisposed population. In humans, as in animals, the major histocompatibility complex plays a preeminent role. Unlike many other autoimmune diseases,...

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