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Article

Tolerance to autoimmune thyroiditis: (CD4+)CD25+ regulatory T cells influence susceptibility but do not supersede MHC class II restriction.

Frontiers in bioscience : a journal and virtual library - 1 May 2006

Morris Gerald P, Kong Yi-chi M

Abstract excerpt

Murine experimental autoimmune thyroiditis (EAT), a model of Hashimoto's thyroiditis, has served for more than three decades as a prototypical model of T cell-mediated autoimmunity. Early investigations demonstrated a clear correlation between genetic factors, particularly the H2A locus of the MHC class II region, and susceptibility to autoimmune thyroiditis. Early studies also demonstrated that susceptibility to...

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Share to Antigens
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Interleukin-2

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Share to T-Lymphocytes, Regulatory

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Share to Thyroiditis, Autoimmune

Source

Identifiers

PMID: 16368509
DOI: 10.2741/1876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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