Article
Efficacy of HLA-DRB1∗03:01 and H2E transgenic mouse strains to correlate pathogenic thyroglobulin epitopes for autoimmune thyroiditis.
Journal of autoimmunity - 1 Sept 2011
Kong Yi-chi M, Brown Nicholas K, Flynn Jeffrey C, McCormick Daniel J, Brusic Vladimir, Morris Gerald P, David Chella S
Abstract excerpt
Thyroglobulin (Tg), a homodimer of 660 kD comprising 2748 amino acids, is the largest autoantigen known. The prevalence of autoimmune thyroid disease, including Hashimoto's thyroiditis and Graves' disease, has provided the impetus for identifying pathogenic T cell epitopes from human Tg over two decades. With no known dominant epitopes, the search has long been a challenge for investigators. After identifying...
Topics
- Animals
- Autoantigens
- Binding Sites
- Cells, Cultured
- Computational Biology
- Disease Models, Animal
- Epitope Mapping
- Epitopes, T-Lymphocyte
- Genetic Predisposition to Disease
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
- Humans