Article
Autoimmune thyroiditis as an indicator of autoimmune sequelae during cancer immunotherapy.
Autoimmunity reviews - 1 Sept 2009
Kong Yi-chi M, Jacob Jennifer B, Flynn Jeffrey C, Elliott Bruce E, Wei Wei-Zen
Abstract excerpt
Improving cancer immunotherapy by targeting T cell network also triggers autoimmunity. We disrupted regulatory T cell (Treg) function to probe the balance between breast cancer vaccination and autoimmune thyroiditis (EAT) in four models, with particular attention to MHC-associated susceptibility, EAT induction with mouse thyroglobulin (mTg) without adjuvant, and tolerance to Her-2/neu in transgenic mice. 1) In...
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