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Article

Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 2002

Myung Kyungjae, Kolodner Richard D

Abstract excerpt

Cancer cells show increased genome rearrangements, although it is unclear what defects cause these rearrangements. Previous studies have implicated the Saccharomyces cerevisiae replication checkpoint in the suppression of spontaneous genome rearrangements. In the present study, low doses of methyl methane sulfonate that activate the intra-S checkpoint but not the G1 or G2 DNA damage checkpoints were found to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11917116
DOI: 10.1073/pnas.062702199
PMCID: PMC123677

Genes

MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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