Article
Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.
Human molecular genetics - 1 Feb 2005
Sang Tzu-Kang, Li Chenjian, Liu Wencheng, Rodriguez Antony, Abrams John M, Zipursky S Lawrence, Jackson George R
Abstract excerpt
Huntington's disease (HD) is caused by expansion of a polyglutamine tract near the N-terminal of huntingtin. Mutant huntingtin forms aggregates in striatum and cortex, where extensive cell death occurs. We used a Drosophila polyglutamine peptide model to assess the role of specific cell death regulators in polyglutamine-induced cell death. Here, we report that polyglutamine-induced cell death was dramatically...
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