Article
A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.
Nature genetics - 1 Apr 2002
Kazantsev Aleksey, Walker Heli A, Slepko Natalia, Bear James E, Preisinger Elizabeth, Steffan Joan S, Zhu Ya-Zhen, Gertler Frank B, Housman David E, Marsh J Lawrence, Thompson Leslie M
Abstract excerpt
Huntington disease is caused by the expansion of a polyglutamine repeat in the Huntingtin protein (Htt) that leads to degeneration of neurons in the central nervous system and the appearance of visible aggregates within neurons. We have developed and tested suppressor polypeptides that bind mutant Htt and interfere with the process of aggregation in cell culture. In a Drosophila model, the most potent suppressor...
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