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Article

Neurodegeneration caused by polyglutamine expansion is regulated by P-glycoprotein in Drosophila melanogaster.

Genetics - 1 Nov 2013

Yadav Suman, Tapadia Madhu G

Abstract excerpt

Trinucleotide CAG repeat disorders are caused by expansion of polyglutamine (polyQ) domains in certain proteins leading to fatal neurodegenerative disorders and are characterized by accumulation of inclusion bodies in the neurons. Clearance of these inclusion bodies holds the key to improve the disease phenotypes, which affects basic cellular processes such as transcription, protein degradation and cell...

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Identifiers

PMID: 24037265
DOI: 10.1534/genetics.113.155077
PMCID: PMC3813869

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