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Article

Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium.

Human molecular genetics - 1 Feb 2005

Kikkawa Yoshiaki, Mburu Philomena, Morse Sue, Kominami Ryo, Townsend Stuart, Brown Steve D M

Abstract excerpt

Little is known of the molecular processes that lead to the growth of stereocilia on the surface of hair cells in the inner ear. The PDZ protein whirlin is known, by virtue of the whirler mutation, to be involved in the process of stereocilia elongation and actin polymerization in the sensory hair cells of mammals. We have investigated the function of whirlin and its putative interacting partner, myosin XVa, in...

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Source

Identifiers

PMID: 15590699
DOI: 10.1093/hmg/ddi035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium.PMID 15590699Read ↗

Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.Semantic proximity Read ↗

The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development.Semantic proximity Read ↗

Elongation of hair cell stereocilia is defective in the mouse mutant whirler.Semantic proximity Read ↗

Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.Semantic proximity Read ↗

Gene Therapy Restores Hair Cell Stereocilia Morphology in Inner Ears of Deaf Whirler MiceSemantic proximity Read ↗

Whirler mutant hair cells have less severe pathology than shaker 2 or double mutants.Semantic proximity Read ↗

Whirlin complexes with p55 at the stereocilia tip during hair cell development.Semantic proximity Read ↗

Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D and DFNB31.Semantic proximity Read ↗

Auditory mechanotransduction in the absence of functional myosin-XVa.Semantic proximity Read ↗

Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle.Semantic proximity Read ↗

β-Actin and fascin-2 cooperate to maintain stereocilia length.Semantic proximity Read ↗

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase patternSemantic proximity Read ↗

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