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Article

Whirler mutant hair cells have less severe pathology than shaker 2 or double mutants.

Journal of the Association for Research in Otolaryngology : JARO - 1 Sept 2007

Mustapha Mirna, Beyer Lisa A, Izumikawa Masahiko, Swiderski Donald L, Dolan David F, Raphael Yehoash, Camper Sally A

Abstract excerpt

MYOSIN XV is a motor protein that interacts with the PDZ domain-containing protein WHIRLIN and transports WHIRLIN to the tips of the stereocilia. Shaker 2 (sh2) mice have a mutation in the motor domain of MYOSIN XV and exhibit congenital deafness and circling behavior, probably because of abnormally short stereocilia. Whirler (wi) mice have a similar phenotype caused by a deletion in the third PDZ domain of...

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Identifiers

PMID: 17619105
DOI: 10.1007/s10162-007-0083-x
PMCID: PMC2538434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Whirler mutant hair cells have less severe pathology than shaker 2 or double mutants.PMID 17619105Read ↗

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