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Article

Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.

Molecular and cellular biology - 1 Mar 2008

Prosser Haydn M, Rzadzinska Agnieszka K, Steel Karen P, Bradley Allan

Abstract excerpt

We have developed a bacterial artificial chromosome transgenesis approach that allowed the expression of myosin VIIa from the mouse X chromosome. We demonstrated the complementation of the Myo7a null mutant phenotype producing a fine mosaic of two types of sensory hair cells within inner ear epithelia of hemizygous transgenic females due to X inactivation. Direct comparisons between neighboring auditory hair...

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Identifiers

PMID: 18160714
DOI: 10.1128/MCB.01282-07
PMCID: PMC2258769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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