Article
Whirlin complexes with p55 at the stereocilia tip during hair cell development.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2006
Mburu Philomena, Kikkawa Yoshiaki, Townsend Stuart, Romero Rosario, Yonekawa Hiromichi, Brown Steve D M
Abstract excerpt
Hearing in mammals depends upon the proper development of actin-filled stereocilia at the hair cell surface in the inner ear. Whirlin, a PDZ domain-containing protein, is expressed at stereocilia tips and, by virtue of mutations in the whirlin gene, is known to play a key role in stereocilia development. We show that whirlin interacts with the membrane-associated guanylate kinase (MAGUK) protein, erythrocyte...
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