Article
Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype.
The Journal of biological chemistry - 18 Feb 2005
Ye Ling, Mishina Yuji, Chen Di, Huang Haiyang, Dallas Sarah L, Dallas Mark R, Sivakumar Pitchumani, Kunieda Tetsuo, Tsutsui Takeo W, Boskey Adele, Bonewald Lynda F, Feng Jian Q
Abstract excerpt
Understanding the molecular mechanisms by which cartilage formation is regulated is essential toward understanding the physiology of both embryonic bone development and postnatal bone growth. Although much is known about growth factor signaling in cartilage formation, the regulatory role of noncollagenous matrix proteins in this process are still largely unknown. In the present studies, we present evidence for a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.