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Article

DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2010

Jiang Baichun, Cao Zhengguo, Lu Yongbo, Janik Carol, Lauziere Stephanie, Xie Yixia, Poliard Anne, Qin Chunlin, Ward Leanne M, Feng Jian Q

Abstract excerpt

DMP1 mutations in autosomal recessive hypophosphatemic rickets (ARHR) patients and mice lacking Dmp1 display an overlapping pathophysiology, such as hypophosphatemia. However, subtle differences exist between the mouse model and human ARHR patients. These differences could be due to a species spe...

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Share to Extracellular Matrix Proteins
Share to Familial Hypophosphatemic Rickets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor-23

Share to In Situ Hybridization

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Source

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Identifiers

PMID: 20499360
DOI: 10.1002/jbmr.117
PMCID: PMC3153318

Genes

DMP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20499360-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.PMID 20499360Read ↗

Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets.Semantic proximity Read ↗

Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.Semantic proximity Read ↗

A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice.Semantic proximity Read ↗

The role of DMP1 in autosomal recessive hypophosphatemic rickets.Semantic proximity Read ↗

Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine SyndromeSemantic proximity Read ↗

First report in Argentina of a pathogenic DMP1 variant associated with autosomal recessive hypophosphatemic rickets.Semantic proximity Read ↗

The First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1.Semantic proximity Read ↗

Studies of the DMP1 57-kDa Functional Domain both in vivo and in vitroSemantic proximity Read ↗

Long-term clinical outcome and carrier phenotype in autosomal recessive hypophosphatemia caused by a novel DMP1 mutation.Semantic proximity Read ↗

Identification of a novel dentin matrix protein-1 (DMP-1) mutation and dental anomalies in a kindred with autosomal recessive hypophosphatemia.Semantic proximity Read ↗

Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome.Semantic proximity Read ↗

DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.Semantic proximity Read ↗

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